Live demonstration: Hardware implementation of convolutional STDP for on-line visual feature learning

We present live demonstration of a hardware that can learn visual features on-line and in real-time during presentation of objects. Input Spikes are coming from a bio-inspired silicon retina or Dynamic Vision Sensor (DVS) and are processed in a Spiking Convolutional Neural Network (SCNN) that is equipped with a Spike Timing Dependent Plasticity (STDP) learning rule implemented on FPGA

Hardware Implementation of Convolutional STDP for On-line Visual Feature Learning

We present a highly hardware friendly STDP (Spike Timing Dependent Plasticity) learning rule for training Spiking Convolutional Cores in Unsupervised mode and training Fully Connected Classifiers in Supervised Mode. Examples are given for a 2-layer Spiking Neural System which learns in real time features from visual scenes obtained with spiking DVS (Dynamic Vision Sensor) Cameras.EU H2020 grant 644096 “ECOMODE”EU H2020 grant 687299 “NEURAM3”Ministry of Economy and Competitivity (Spain) /European Regional Development Fund TEC2012-37868-C04-01 (BIOSENSE)Junta de Andalucía (España) TIC-6091 (NANONEURO

An AER handshake-less modular infrastructure PCB with x8 2.5Gbps LVDS serial links

Nowadays spike-based brain processing emulation is taking off. Several EU and others worldwide projects are demonstrating this, like SpiNNaker, BrainScaleS, FACETS, or NeuroGrid. The larger the brain process emulation on silicon is, the higher the communication performance of the hosting platforms has to be. Many times the bottleneck of these system implementations is not on the performance inside a chip or a board, but in the communication between boards. This paper describes a novel modular Address-Event-Representation (AER) FPGA-based (Spartan6) infrastructure PCB (the AER-Node board) with 2.5Gbps LVDS high speed serial links over SATA cables that offers a peak performance of 32-bit 62.5Meps (Mega events per second) on board-to-board communications. The board allows back compatibility with parallel AER devices supporting up to x2 28-bit parallel data with asynchronous handshake. These boards also allow modular expansion functionality through several daughter boards. The paper is focused on describing in detail the LVDS serial interface and presenting its performance.Ministerio de Ciencia e Innovación TEC2009-10639-C04-02/01Ministerio de Economía y Competitividad TEC2012-37868-C04-02/01Junta de Andalucía TIC-6091Ministerio de Economía y Competitividad PRI-PIMCHI-2011-076

MOSFET mismatch in weak/moderate inversion : model needs and implications for analog design

PostprintTrabajo presentado en ESSCIRC 2004. 29th European Solid-State Circuits Conference, Estoril, Portugal, 2003Based on mismatch measurements performed on very different CMOS technologies and large operating temperature range, we propose to model more adequately the mismatch in weak and moderate inversion by adding a new term related to the mismatch of the body effect factor dependence on the gate voltage. The model is introduced in a top-down analog design methodology, applied to the current mirror case, revealing some nonobvious design rules as well as typical misconceptions

Live Demonstration: Multiplexing AER Asynchronous Channels over LVDS Links with Flow-Control and Clock- Correction for Scalable Neuromorphic Systems

In this live demonstration we exploit the use of a serial link for fast asynchronous communication in massively parallel processing platforms connected to a DVS for realtime implementation of bio-inspired vision processing on spiking neural networks

Implementation of binary stochastic STDP learning using chalcogenide-based memristive devices

The emergence of nano-scale memristive devices encouraged many different research areas to exploit their use in multiple applications. One of the proposed applications was to implement synaptic connections in bio-inspired neuromorphic systems. Large-scale neuromorphic hardware platforms are being developed with increasing number of neurons and synapses, having a critical bottleneck in the online learning capabilities. Spike-timing-dependent plasticity (STDP) is a widely used learning mechanism inspired by biology which updates the synaptic weight as a function of the temporal correlation between pre- and post-synaptic spikes. In this work, we demonstrate experimentally that binary stochastic STDP learning can be obtained from a memristor when the appropriate pulses are applied at both sides of the device

Bright Field Microscopy as an Alternative to Whole Cell Fluorescence in Automated Analysis of Macrophage Images

Fluorescence microscopy is the standard tool for detection and analysis of cellular phenomena. This technique, however, has a number of drawbacks such as the limited number of available fluorescent channels in microscopes, overlapping excitation and emission spectra of the stains, and phototoxicity.We here present and validate a method to automatically detect cell population outlines directly from bright field images. By imaging samples with several focus levels forming a bright field -stack, and by measuring the intensity variations of this stack over the -dimension, we construct a new two dimensional projection image of increased contrast. With additional information for locations of each cell, such as stained nuclei, this bright field projection image can be used instead of whole cell fluorescence to locate borders of individual cells, separating touching cells, and enabling single cell analysis. Using the popular CellProfiler freeware cell image analysis software mainly targeted for fluorescence microscopy, we validate our method by automatically segmenting low contrast and rather complex shaped murine macrophage cells.The proposed approach frees up a fluorescence channel, which can be used for subcellular studies. It also facilitates cell shape measurement in experiments where whole cell fluorescent staining is either not available, or is dependent on a particular experimental condition. We show that whole cell area detection results using our projected bright field images match closely to the standard approach where cell areas are localized using fluorescence, and conclude that the high contrast bright field projection image can directly replace one fluorescent channel in whole cell quantification. Matlab code for calculating the projections can be downloaded from the supplementary site: http://sites.google.com/site/brightfieldorstaining

A Comprehensive Workflow for General-Purpose Neural Modeling with Highly Configurable Neuromorphic Hardware Systems

In this paper we present a methodological framework that meets novel requirements emerging from upcoming types of accelerated and highly configurable neuromorphic hardware systems. We describe in detail a device with 45 million programmable and dynamic synapses that is currently under development, and we sketch the conceptual challenges that arise from taking this platform into operation. More specifically, we aim at the establishment of this neuromorphic system as a flexible and neuroscientifically valuable modeling tool that can be used by non-hardware-experts. We consider various functional aspects to be crucial for this purpose, and we introduce a consistent workflow with detailed descriptions of all involved modules that implement the suggested steps: The integration of the hardware interface into the simulator-independent model description language PyNN; a fully automated translation between the PyNN domain and appropriate hardware configurations; an executable specification of the future neuromorphic system that can be seamlessly integrated into this biology-to-hardware mapping process as a test bench for all software layers and possible hardware design modifications; an evaluation scheme that deploys models from a dedicated benchmark library, compares the results generated by virtual or prototype hardware devices with reference software simulations and analyzes the differences. The integration of these components into one hardware-software workflow provides an ecosystem for ongoing preparative studies that support the hardware design process and represents the basis for the maturity of the model-to-hardware mapping software. The functionality and flexibility of the latter is proven with a variety of experimental results

Robust Automated Tumour Segmentation on Histological and Immunohistochemical Tissue Images

Tissue microarray (TMA) is a high throughput analysis tool to identify new diagnostic and prognostic markers in human cancers. However, standard automated method in tumour detection on both routine histochemical and immunohistochemistry (IHC) images is under developed. This paper presents a robust automated tumour cell segmentation model which can be applied to both routine histochemical tissue slides and IHC slides and deal with finer pixel-based segmentation in comparison with blob or area based segmentation by existing approaches. The presented technique greatly improves the process of TMA construction and plays an important role in automated IHC quantification in biomarker analysis where excluding stroma areas is critical. With the finest pixel-based evaluation (instead of area-based or object-based), the experimental results show that the proposed method is able to achieve 80% accuracy and 78% accuracy in two different types of pathological virtual slides, i.e., routine histochemical H&E and IHC images, respectively. The presented technique greatly reduces labor-intensive workloads for pathologists and highly speeds up the process of TMA construction and provides a possibility for fully automated IHC quantification